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The Henderson-Hasselbalch equation allows us to determine the charge state of any ionizable group given its pKa

Thats because orforglipron is a non-peptide, small-molecule pill, so it doesnt bind to the GLP-1 receptor quite as strongly as injectable peptide medications, which mimic our bodys natural GLP-1 hormone, Kumar explained

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Moreover, depressed patients show a reduction in synaptic density proteins in response to stress (Kang et al., 2012)

Slowing gastric emptying, which delays nutrient absorption and blunts postprandial glucose excursions